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This workshop is a 2-day Masterclass for all physicians interested in developing and advancing their skills in the field of integrative medicine by reviewing new approaches to complex medical cases. It constitutes a clinical systems biology approach to medicine, with particular emphasis on the role the immune system plays in a variety of chronic illnesses. This practical exploration of metabolism organizes complex patient presentations into distinct, measurable sub-categories to ensure effective assessment and individualized wellness plan development and execution. Adequate time will be devoted to case analysis, group discussion and translation of knowledge into critical thinking skills.